Antibiotics, Resistome and Resistance Mechanisms: A Bacterial Perspective

Frontiers in Microbiology

Aftab Hossain Mondal¹  Mohammad Tahir Siddiqui¹  Insha Sultan¹  Qazi Mohd Rizwanul Haq¹  Safikur Rahman²  Arif Tasleem Jan³ 

[1] Department of Biosciences, Jamia Millia Islamia, New Delhi, India;Department of Medical Biotechnology, Yeungnam University, Gyeongsan, South Korea;School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, India;

关键词: antibiotics;    bacteria;    bacterial resistance;    diseases;    health care;   

DOI  :  10.3389/fmicb.2018.02066

来源: DOAJ

【 摘 要 】

History of mankind is regarded as struggle against infectious diseases. Rather than observing the withering away of bacterial diseases, antibiotic resistance has emerged as a serious global health concern. Medium of antibiotic resistance in bacteria varies greatly and comprises of target protection, target substitution, antibiotic detoxification and block of intracellular antibiotic accumulation. Further aggravation to prevailing situation arose on observing bacteria gradually becoming resistant to different classes of antibiotics through acquisition of resistance genes from same and different genera of bacteria. Attributing bacteria with feature of better adaptability, dispersal of antibiotic resistance genes to minimize effects of antibiotics by various means including horizontal gene transfer (conjugation, transformation, and transduction), Mobile genetic elements (plasmids, transposons, insertion sequences, integrons, and integrative-conjugative elements) and bacterial toxin-antitoxin system led to speedy bloom of antibiotic resistance amongst bacteria. Proficiency of bacteria to obtain resistance genes generated an unpleasant situation; a grave, but a lot unacknowledged, feature of resistance gene transfer.

【 授权许可】

Unknown