Cadherin-based biomaterials: Inducing stem cell fate towards tissue construction and therapeutics

Progress in Natural Science: Materials International

Zheng Qin¹  Zhanyuan Qu²  Min Ge²  Yan Zhang²  Jun Yang² 

[1] State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300350, China;The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, China;

关键词: Cadherin;    Mimic cell-cell interactions;    Biomaterials;    Stem cell;    Tissue construction;   

DOI  :  

来源: DOAJ

【 摘 要 】

The precise regulation of cell fate by biomaterials is one of the core focuses in tissue engineering and regenerative therapeutics. Cell fate is controlled by the niche signaling cues, including growth factors/morphogens, direct cell-cell contact, and extracellular matrix components. Here, we discuss how to bio-mimic cell-cell interaction by tailoring the interface of biomaterials to design effective scaffolds. Cadherins, as a key cell membrane protein family mediating the intercellular adherens junction, have attracted extensive attention in the functional modification of biomaterials. Therefore, cadherin-based biomaterials, their ability to modulate stem cell fate, and their applications in regenerative medicine are reviewed. Furthermore, we provide an outlook for exploiting the bio-mimic biomaterials in advanced cell therapeutics.

【 授权许可】

Unknown