Saikosaponin A attenuates neural injury caused by ischemia/reperfusion

Translational Neuroscience

Yang Guofeng¹  Wang Xinying² 

[1] Department of Neurology, Harrison International Peace Hospital, No.180, East Renmin Road, Hengshui 053000, Hebei, China;Department of Neurology, Hebei Medical University, No. 361, East Zhongshan Road, Shijiazhuang 050017, Hebei, China;

关键词: ischemia;    neuroprotection;    stroke;    toll-like receptors;    hmgb1;   

DOI  :  10.1515/tnsci-2020-0129

来源: DOAJ

【 摘 要 】

Inflammation is involved in cerebral ischemia/reperfusion (I/R)-induced neurological damage. Saikosaponin A (SSa), extracted from Radix bupleuri, has been reported to exert anti-inflammatory effects. This article aimed to investigate whether SSa could ameliorate neuroinflammation mediated by ischemic stroke and the underlying mechanism.

【 授权许可】

Unknown