Frontiers in Nutrition | |
Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression | |
Rita Businaro1  David Vauzour2  Pedro Zuzarte4  Gerald Münch5  Erika Gyengesi5  Laura Brogelli6  Jerome Sarris7  | |
[1] Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy;Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich, United Kingdom;NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia;Neuropsychiatry Research Department, GNR Clinical Center, Lisbon, Portugal;Pharmacology Unit, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia;Polistudium srl, Millan, Italy;Professorial Unit, The Melbourne Clinic, Department of Psychiatry, Melbourne University, Melbourne, VIC, Australia;Psychiatric Clinic, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; | |
关键词: brain health; depression; neuroinflammation; diet; gut-brain axis; | |
DOI : 10.3389/fnut.2021.669846 | |
来源: DOAJ |
【 摘 要 】
Emerging evidence is showing nutrition as a crucial factor in the high prevalence and incidence of neurodegenerative mental disorders. Preventive interventions on neuroinflammation seem to be able to interfere with neurodegeneration. Supplementation of essential nutrients, such as long-chain-polyunsaturated fatty acids, vitamin E and mineral elements, may minimize inflammation, enhancing antioxidative defense, and lowering the risk and incidence of age-related diseases, such as cardiovascular diseases and neurodegenerative diseases. This manuscript reviews the current evidence on the role of neuroinflammation in the pathophysiology of neurodegenerative and mental disorders, and preventive strategies for food supplementation in these neuropsychiatric diseases. Dietary supplementation-based strategies have been demonstrated to be effective in subjects with mild cognitive impairment, while weaker results have been obtained in patients with advance neurodegenerative disease. Adjunctive supplementation has also been demonstrated to improve depression, this being of marked benefit considering the comorbidity between cognitive impairment/dementia and depression. Further research is needed to improve the prescriptive precision of supplementation in patients, and to better understand potential interactions with clinical and pharmacokinetic factors.
【 授权许可】
Unknown