Molecular Mechanisms and Current Treatment Options for Cancer Cachexia

Cancers

Khurshid Ahmad¹  Sibhghatulla Shaikh¹  Syed Sayeed Ahmad¹  Eun Ju Lee¹  Inho Choi¹  Shahid Ali²  Eun-Young Lee³  Hye Jin You³ 

[1] Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, Korea;Research Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Gyeongsangbuk-do, Korea;Tumor Microenvironment Branch, Division of Cancer Biology, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Gyeonggi-do, Korea;

关键词: cancer cachexia;    skeletal muscle;    inhibitors;    myostatin;    natural compounds;   

DOI  :  10.3390/cancers14092107

来源: DOAJ

【 摘 要 】

Cancer cachexia is a condition marked by functional, metabolic, and immunological dysfunctions associated with skeletal muscle (SM) atrophy, adipose tissue loss, fat reduction, systemic inflammation, and anorexia. Generally, the condition is caused by a variety of mediators produced by cancer cells and cells in tumor microenvironments. Myostatin and activin signaling, IGF-1/PI3K/AKT signaling, and JAK-STAT signaling are known to play roles in cachexia, and thus, these pathways are considered potential therapeutic targets. This review discusses the current state of knowledge of the molecular mechanisms underlying cachexia and the available therapeutic options and was undertaken to increase understanding of the various factors/pathways/mediators involved and to identify potential treatment options.

【 授权许可】

Unknown