Cancer Treatment and Research Communications | |
The prognostic impact of circulating miRNAs in patients with advanced esophagogastric cancer during palliative chemotherapy | |
Roza C.M. Opperman1  Hans J. van der Vliet2  Henk M.W. Verheul3  Annette A. van Zweeden3  Godefridus J. Peters3  Richard J. Honeywell3  Dennis Poel3  | |
[1] Amstelland Hospital, Internal Medicine, Amstelveen, Netherlands,;Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland,;Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Department of Medical Oncology, Amsterdam, Netherlands,; | |
关键词: Esophagogastric cancer; Cisplatin; Gemcitabine; Vitamin B12; MicroRNA; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
The prognosis of patients with advanced oesophageal cancer (EC) and gastric cancer (GC) is poor. Circulating microRNAs (ci-miRNAs) may have prognostic and predictive value to improve patient selection for palliative treatment. The purpose of this study is to assess the prognostic and predictive value of specific ci-miRNAs in plasma of patients with EC and GC treated with first-line palliative gemcitabine and cisplatin. Droplet digital PCR (ddPCR) was used to quantify miR-200c-3p, miR-375, miR-21-5p, miR-148a-3p, miR-146a-5p, miR-141-3p and miR-218-5p in plasma from 68 patients. ci-miRNA expression was analyzed in relation to overall survival (OS), progression-free survival (PFS), and response to chemotherapy. ci-miRNA levels were detectable in 36 baseline (71%) samples and in 14 (47%) follow-up samples. Increased circulating miR-200c-3p in GC showed a trend (p = 0.06) towards a shorter OS. High circulating miR-375 was associated with a longer OS (p = 0.02) in patients with esophageal adenocarcinoma (EAC). No significant difference was observed in ci-miRNA expression between paired pre- and on-treatment samples. ci-miRNA expression was not associated with response to chemotherapy. ci-miRNAs can be measured in plasma samples of patients treated with first-line palliative chemotherapy using ddPCR despite prolonged storage in heparin. Elevated circulating miR-375 might be a prognostic marker for patients with EAC.
【 授权许可】
Unknown