Experience of effective antiviral therapy in a liver recipient with recurrent HCV infection genotype 1

Vestnik Transplantologii i Iskusstvennyh Organov

I. A. Miloserdov¹  E. T. Egorova¹  R. A. Latypov²  D. V. Umrik²  O. M. Tsiroulnikova² 

[1] I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University);V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation;

关键词: chronic hepatitis c;    relapse;    liver transplantation;    direct antiviral action;    resistant virologic response;   

DOI  :  10.15825/1995-1191-2018-4-54-60

来源: DOAJ

【 摘 要 】

HCV infection is one of the most common causes leading to the development of terminal liver diseases – cirrhosis and hepatocellular carcinoma, the main treatment for which is orthotopic liver transplantation. However, with continued virus replication, 100% reinfection occurs, which leads to the rapid progression of cirrhosis of the graft and the loss of its function. Standard interferon-containing therapy is ineffective for HCV infection, especially genotype 1, both before and after transplantation, and also has a wide range of adverse events. The article presents the successful experience of treating the recurrence of HCV infection 1 genotype in a patient who underwent liver transplantation and several courses of ineffective antiviral therapy.

【 授权许可】

Unknown