Vestnik Transplantologii i Iskusstvennyh Organov | |
Experience of effective antiviral therapy in a liver recipient with recurrent HCV infection genotype 1 | |
I. A. Miloserdov1  E. T. Egorova1  R. A. Latypov2  D. V. Umrik2  O. M. Tsiroulnikova2  | |
[1] I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovsky University);V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs of the Ministry of Healthcare of the Russian Federation; | |
关键词: chronic hepatitis c; relapse; liver transplantation; direct antiviral action; resistant virologic response; | |
DOI : 10.15825/1995-1191-2018-4-54-60 | |
来源: DOAJ |
【 摘 要 】
HCV infection is one of the most common causes leading to the development of terminal liver diseases – cirrhosis and hepatocellular carcinoma, the main treatment for which is orthotopic liver transplantation. However, with continued virus replication, 100% reinfection occurs, which leads to the rapid progression of cirrhosis of the graft and the loss of its function. Standard interferon-containing therapy is ineffective for HCV infection, especially genotype 1, both before and after transplantation, and also has a wide range of adverse events. The article presents the successful experience of treating the recurrence of HCV infection 1 genotype in a patient who underwent liver transplantation and several courses of ineffective antiviral therapy.
【 授权许可】
Unknown