期刊论文详细信息
Frontiers in Bioengineering and Biotechnology
Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressing for Therapy of Full-Thickness Skin Wounds
Jintao Yang1  Xiao Zhao2  Dong Zhang3  Shuguang Wang4  Junjian Liu5  Liping Nan5  Desheng Wu6  Feng Wang6  Ziqi Zhu6  Jiawei Lu6 
[1] College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, China;Department of Anesthesiology, Shanghai General Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China;Department of Chemical, Biomolecular, and Corrosion Engineering, College of Engineering and Polymer Science, The University of Akron, Akron, OH, United States;Department of Orthopedic, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China;Department of Orthopedic, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;Department of Spine Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China;
关键词: conductive hydrogel;    adhesive hydrogel;    antibacterial hydrogel;    wound dressing;    wound healing;   
DOI  :  10.3389/fbioe.2022.833887
来源: DOAJ
【 摘 要 】

Any sort of wound injury leads to the destruction of skin integrity and wound formation, causing millions of deaths every year and accounting for 10% of death rate insight into various diseases. The ideal biological wound dressings are expected to possess extraordinary mechanical characterization, cytocompatibility, adhesive properties, antibacterial properties, and conductivity of endogenous electric current to enhance the wound healing process. Recent studies have demonstrated that biomedical hydrogels can be used as typical wound dressings to accelerate the whole healing process due to them having a similar composition structure to skin, but they are also limited by ideal biocompatibility and stable mechanical properties. To extend the number of practical candidates in the field of wound healing, we designed a new structural zwitterion poly[3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) into a poly-acrylamide network, with remarkable mechanical properties, stable rheological property, effective antibacterial properties, strong adsorption, high penetrability, and good electroactive properties. Both in vivo and in vitro evidence indicates biocompatibility, and strong healing efficiency, indicating that poly (AAm-co-SVBA) (PAS) hydrogels as new wound healing candidates with biomedical applications.

【 授权许可】

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