Dysfunction of B Cell Leading to Failure of Immunoglobulin Response Is Ameliorated by Dietary Silk Peptide in 14-Month-Old C57BL/6 Mice

Frontiers in Nutrition

Hyun-Ji Oh¹  Boo-Yong Lee¹  Kippeum Lee¹  Heegu Jin¹  Sungwoo Chei¹  Jeong-Yong Lee² 

[1] Department of Biomedical Sciences, CHA University, Pocheon, South Korea;Worldway Co., Ltd., Sejong, South Korea;

关键词: immunosenescence;    senescence;    aging;    acid-hydrolyzed silk peptide;    adaptive immunity;    B cell;   

DOI  :  10.3389/fnut.2020.583186

来源: DOAJ

【 摘 要 】

Anti-aging research suggests that immunosenescent cells can play deleterious roles in the immune system. Here, young (2 months old) and old (14 months old) C57BL/6 mice received a daily oral dose (100 or 750 mg/kg/day) of acid-hydrolyzed silk peptide (SP) for a period of 5 weeks. Mouse spleen, lymph node, and serum were analyzed to determine the immune homeostasis of SP by flow cytometry, Western blotting, ELISA, and qRT-PCR. The results suggest that SP ameliorates age-related dysfunction of T and B cells. Amelioration of B cell dysfunction improved the immunoglobulin response in aged mice. Taken together, the results suggest that SP restores immune homeostasis with respect to immunosenescent cells.

【 授权许可】

Unknown