The frequency of genetic markers of the folate cycle in newborns with intrauterine growth retardation

Rossijskij Vestnik Perinatologii i Pediatrii

A. N. Ni¹  T. Yu. Fadeeva¹  S. N. Shishatskaya¹  T. G. Vasilyeva² 

[1] Pacific State Medical University;ГАУЗ «Краевой клинический центр специализированных видов медицинской помощи», Владивосток;

关键词: fetus;    newborn;    intrauterine growth retardation;    mthfr;    mtr;    mtrr genes;    folate cycle;   

DOI  :  

来源: DOAJ

【 摘 要 】

The article presents the results of an investigation of the frequency of genetic markers of the folate cycle in 24 neonates with the hypotrophic or hypoplastic types of intrauterine growth retardation (IUGR). The investigators examined the polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, such as S677S, C677T, and T677T, the methionine synthase (MTR) gene, such as A2756A, A2756G, and G2756G, and the methionine synthase reductase (MTRR) gene, such as G66G, G66A, and A66A. The analysis established an association of the occurrence of IUGR in neonates with MTHFR T677T, MTR G2756G, and MTRR A66A polymorphisms; this is especially relevant in the hypotrophic type of IUGR and in boys. Identification of risk groups and genetic analysis of folic acid metabolism allow the choice of an effective package of measures to prevent IUGR.

【 授权许可】

Unknown