Recent advances in 4-aminoquinazoline based scaffold derivatives targeting EGFR kinases as anticancer agents

Future Journal of Pharmaceutical Sciences

Sahar Abuserii¹  Nasser S.M. Ismail²  Dalal A. Abou El Ella³  Rania S.M. Ismail⁴ 

[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box, 11562, Egypt;Pharmaceutical Chemistry Department, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University, Cairo, 12311, Egypt;Pharmaceutical Chemistry Department, Faculty of Pharmacy Ain Shams University, Abbassia, Cairo 11566, Egypt;Pharmaceutical Chemistry Department, Faculty of Pharmacy Egyptian Russian University, Badr City, Suez Road, Egypt;

关键词: Quinazolines;    EGFR inhibitors;    Protein kinases;    Tyrosine kinase inhibitors;   

DOI  :  10.1016/j.fjps.2016.02.001

来源: DOAJ

【 摘 要 】

Quinazoline derivatives are fused heterocyclic ring systems which have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents. The present review to represent the most recent synthetic strategies and medicinal aspects including structure activity relationships of substituted quinazolines as EGFR inhibitors reported to date.

【 授权许可】

Unknown