Improved Synthesis of Substituted 6,7-Dihydroxy-4-quinazolineamines: Tandutinib, Erlotinib and Gefitinib

Molecules

Petr Knesl¹  Dirk Röseling¹ 

[1] id="af1-molecules-11-00286">Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, 1060 Vienna, Austr

关键词: Quinazolines;    tyrosine kinase inhibitors;   

DOI  :  10.3390/11040286

来源: mdpi

【 摘 要 】

The synthesis of three substituted 6,7-dihydroxy-4-quinazolineamines: tandutinib (1), erlotinib (2) and gefitinib (3) in improved yields is reported. The intermediates were characterized by NMR and the purities determined by HPLC.

【 授权许可】

Unknown   
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