Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats

Journal of Functional Foods

Rasha S. Albeltagy¹  Doaa M. Abdel-Mohsen²  Ahmed E. Abdel Moneim²  Shahenda Mahgoub²  Ahmed M. A. Akabawy³  Hatem K. Amin³  Ohoud D. AlAmri⁴ 

[1] Corresponding authors.;Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt;Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt;Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia;

关键词: High-fat diet;    STZ;    Green coffee;    Renal function;    Apoptosis;    Inflammation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses of green coffee on biomarkers related to renal and antioxidant systems. The study was carried out on 42 diabetic male albino rats; a high-fat diet (HFD) and a single dose of streptozotocin (STZ; 35 mg kg−1) were utilized for model induction. Diabetic rats were received green coffee water extract (GCWE; 50 and 100 mg kg−1) daily for 28 days. GCWE caused a remarkable recovery of kidney weight, kidney function, and aldosterone level, particularly. Proapoptotic, antiapoptotic and inflammatory markers were significantly improved and showing a great retain to their normal levels specifically in GCWE-treated groups. Also, a marked improvement in the antioxidants defense system was noted. GCWE has a great protective influence on kidney injury of HFD/STZ‐induced diabetic rats.

【 授权许可】

Unknown