Regulatory effect of miRNAs on apoptosis, migration, and cell cycle of hepatocellular carcinoma cells

Linchuang Gandanbing Zazhi

XU Li¹ 

[1] Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, China;

关键词: liver neoplasms;    microRNAs;    apoptosis;    neoplasm metastasis;    neoplasm invasiveness;    cell cycle;   

DOI  :  10.3969/j.issn.1001-5256.2013.07.021

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules of about 22 nucleotides in length that are encoded by endogenous gene and participate in post-transcriptional regulation of gene expression. Many evidences indicate that some miRNAs are deregulated in hepatocellular carcinoma (HCC), and it has been found that miRNAs regulate the proliferation, apoptosis, migration, invasion, and cell cycle of HCC cells through some pathways or genes. In addition, some studies suggest that miRNAs function as oncogenes or anti-oncogenes. Therefore, in-depth understanding of the specific role and function of miRNAs in HCC may provide a new approach for the treatment of HCC.

【 授权许可】

Unknown