The effect of fumaric acid-sodium bicarbonate on the green tea effervescent granule’s quality made by dry granulation

Indonesian Journal of Pharmacy

Maria Yuli Trisusilawati¹  Agatha Busi susiati Lestari¹ 

[1] Fakultas Farmasi Universitas Sanata Dharma Yogyakarta;

关键词: green tea;    fumaric acid;    effervescent granule;    dry granulation;   

DOI  :  http://dx.doi.org/10.14499/indonesianjpharm0iss0pp218-224

来源: DOAJ

【 摘 要 】

Tea plant (CamelliasinensisL.)had beenknowntocontains epigallocathecin gallate (EGCG) that can be used to maintain the healthy. In this research, the green tea wastried to be formulated in effervescent dosage form, withthefocusontheeffectamongfumaricacid,sodiumbicarbonate,andthe interactionbetweenfumaricacidandsodiumbicarbonateonthegreentea extracteffervescent granule’sphysical properties, that made by dry granulation method.Physicalpropertiesofeffervescentgranulethatbeenstudywere moisturecontent,flowrate,disintegrationtime,andpHofthesolution.The result showed that sodium bicarbonate was dominant in determining pH, granule flowrateandmoisturecontentofgranule,whereasfumaricaciddominantin disintegration time of effervescent granule.

【 授权许可】

Unknown