Achyrocline satureioides (Lam.) DC., Asteraceae: development of granules from spray dried powder

Revista Brasileira de Farmacognosia

Petrovick, Pedro R.¹  Petrovick, Gustavo F.¹  Bassani, Valquiria L.¹  Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil¹ 

关键词: Achyrocline satureioides;    herbal medicines;    dry granulation;    spray drying.;   

DOI  :  10.1590/S0102-695X2010005000020

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Achyrocline satureioides (Lam.) DC., Asteraceae, is a herbal specie widely used in folk medicine in the south of Brazil, Uruguay, Argentina and Paraguay. The technological characteristics of an Achyrocline satureioides spray dried extract powder, produced in semi-industrial scale, as well as the feasibility of the granules are reported in the present work. The spray dried powder was characterized as a fine powder consisting of small spherical particles with rough and porous surface. The Hausner's factor, Carr's index, and densification index of the spray dried powder were, respectively, 1,23, 18,9%, and 27,2 mL, characterizing it as a poor flow and low density powder. The preparation of granules from this spray dried powder, through dry disaggregation method, yielded irregularly shaped granules, with a rough surface, but with better flow and compactability characteristics. These granules presented a Hausner's factor, a Carr's index, and a densification index of, respectively, 1,09, 8,16%, and 12,33 mL. The LC assay of the main polyphenols, quercetin, luteolin, and 3-O-methylquercetin revealed that the granulation process did not changed the quantitative and qualitative profile of these constituents originally present in the spray dried powder. The comparative evaluation of the physical stability of both the spray dried powder and the granules, under relative humidity conditions of 65% and 99%, showed an expressive reduction in the humidity sorption on the granules as compared to the spray dried powders.

【 授权许可】

Unknown