Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

Biomedicine & Pharmacotherapy

Hamed Mirzaei¹  Ahmad Piroozmand²  Zahra Kargar Jahromi³  Pourya Raee⁴  Vahid Jajarmi⁵  Yazdan Rahmati⁶  Javid Sadri Nahand⁷  Shahin Aghamiri⁸  Sajad Najafi⁸  Zahra Ebrahimi⁸  Shing Cheng Tan⁹ 

[1] Correspondence to: Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19395-4818, Iran.;Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran;Central Research Laboratory, Jahrom University of Medical Sciences, Jahrom, Iran;Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran;Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;

关键词: CRISPR-Cas;    Gene editing;    Infection;    Treatment;    Virus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed.

【 授权许可】

Unknown