Melatonin Suppresses the Growth of Ovarian Cancer Cell Lines (OVCAR-429 and PA-1) and Potentiates the Effect of G1 Arrest by Targeting CDKs

International Journal of Molecular Sciences

Yi-Tz Chen¹  Chi-Chang Chang²  Chung-Sheng Lai³  Yi-Chiang Hsu⁴  Ching-Ju Shen⁴ 

[1] Gynecology, E-Da Hospital, E-Da Hospital/I-Shou University, 82445 Kaohsiung, Taiwan;;Department of Obstetrics &Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, 71101 Tainan, Taiwan;Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807 Kaohsiung, Taiwan;

关键词: ovarian cancer;    melatonin;    cell cycle;    CDK;   

DOI  :  10.3390/ijms17020176

来源: DOAJ

【 摘 要 】

Melatonin is found in animals as well as plants. In animals, it is a hormone that anticipates the daily onset of darkness and regulates physiological functions, such as sleep timing, blood pressure, and reproduction. Melatonin has also been found to have anti-tumor properties. Malignant cancers are the most common cause of death, and the mortality rate of ovarian tumor is the highest among gynecological diseases. This study investigated the anti-tumor effects of melatonin on the ovarian cancer lines, OVCAR-429 and PA-1. We observed the accumulation of melatonin-treated cells in the G1 phase due to the down-regulation of CDK 2 and 4. Our results suggest that in addition to the known effects on prevention, melatonin may also provide anti-tumor activity in established ovarian cancer.

【 授权许可】

Unknown