Kinetics of the Neutralizing and Spike SARS-CoV-2 Antibodies following the Sinovac Inactivated Virus Vaccine Compared to the Pfizer mRNA Vaccine in Singapore

Antibodies

May Lin Helen Oh¹  Tar Choon Aw²  Soon Kieng Phua²  Ya Li Liang²  Chin Shern Lau²  Yanfeng Li³  Shengli Xu⁴  Jianxin Huo⁴  Yuhan Huang⁴  Biyan Zhang⁴ 

[1] Department of Infectious Diseases, Changi General Hospital, Singapore 529889, Singapore;Department of Laboratory Medicine, Changi General Hospital, Singapore 529889, Singapore;GenScript Biotech (Singapore) Pte Ltd., Singapore 349248, Singapore;Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648, Singapore;

关键词: mRNA vaccine;    inactivated virus vaccine;    antibodies;    SARS-CoV-2;   

DOI  :  10.3390/antib11020038

来源: DOAJ

【 摘 要 】

Introduction: We compared the early total spike antibody (S-Ab) and neutralizing antibody (N-Ab) responses to two vaccines. Methods: We studied 96 Pfizer and 34 Sinovac vaccinees over a 14-month period from January 2021 to February 2022. All vaccinees received three doses of one type of vaccine. Antibody levels (Roche Elecsys total S-Ab and the Snibe N-Ab) were tested 10 days after the first dose, 20 days after the second dose, and 20 days after the booster dose. Results: At all time points, the mRNA vaccine generated higher S-Ab and N-Ab responses than the inactivated virus vaccine (S-Ab: first dose 2.48 vs. 0.4 BAU/mL, second dose 2174 vs. 98 BAU/mL, third dose 15,004 vs. 525 BAU/mL; N-Ab: first dose 0.05 vs. 0.02 µg/mL, second dose 3.48 vs. 0.38 µg/mL, third dose 19.8 vs. 0.89 µg/mL). mRNA vaccine recipients had a 6.2/22.2/28.6-fold higher S-Ab and 2.5/9.2/22.2-fold higher N-Ab response than inactivated virus vaccine recipients after the first/second/third inoculations, respectively. Mann–Whitney U analysis confirmed the significant difference in S-Ab and N-Ab titers between vaccination groups at each time point. Conclusions: The mRNA vaccines generated a more robust S-Ab and N-Ab response than the inactivated virus vaccine at all time points after the first, second, and third vaccinations.

【 授权许可】

Unknown