Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 2/3-bromo-N′-(substituted benzylidene/3-phenylallylidene)benzohydrazides

Arabian Journal of Chemistry

Abu Bakar Abdul Majeed¹  Vasudevan Mani¹  Rakesh Kumar Mishra¹  Kalavathy Ramasamy²  Pradeep Kumar³  Balasubramanian Narasimhan³ 

[1] Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia;Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM), 42300 Bandar Puncak Alam, Selangor, Malaysia;Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India;

关键词: Benzohydrazides;    Antimicrobial activity;    Anticancer activity;    QSAR;   

DOI  :  10.1016/j.arabjc.2014.05.010

来源: DOAJ

【 摘 要 】

In the present study, a series of 2/3-bromo-N′-(substituted benzylidene/3-phenylallylidene)benzohydrazides was synthesized and evaluated in vitro for its antimicrobial and anticancer potentials. The results of antimicrobial and anticancer study indicated that compounds 3, 15 and 18 (pMICam = 1.62 μM/ml) were found to be most potent antimicrobial agents and compound 4 (IC50 = 1.88 ± 0.03 μM) was found to be the most potent anticancer agent. The results of QSAR analysis indicated the importance of topological parameters, Balaban index (J) and valence first and second order molecular connectivity indices (1χv and 2χv) in describing antimicrobial activity of the synthesized benzohydrazides.

【 授权许可】

Unknown