Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents

BMC Chemistry

Vasudevan Mani¹  Balasubramanian Narasimhan²  Sanjiv Kumar²  Deepika Sharma²  Kalavathy Ramasamy³  Siong Meng Lim³  Syed Adnan Ali Shah³ 

[1] Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University;Faculty of Pharmaceutical Sciences, Maharshi Dayanand University;Faculty of Pharmacy, Universiti Teknologi MARA (UiTM);

关键词: Synthesis;    Thiazole derivatives;    Antimicrobial activity;    Anticancer activity;    MCF7;    Molecular docking;   

DOI  :  10.1186/s13065-019-0564-0

来源: DOAJ

【 摘 要 】

Abstract To combat the antimicrobial and anticancer drug resistance by pathogens and cancerous cells, efforts has been made to study the pharmacological activities of newly synthesized N-(4-(4-bromophenyl)thiazol-2-yl)-2-chloroacetamide derivatives. The molecular structures of the synthesized derivatives were confirmed by their physicochemical properties and spectroanalytical data (NMR, IR and elemental). The synthesized compounds were evaluated for their in vitro antimicrobial activity against bacterial (Gram positive and Gram negative) and fungal species using turbidimetric method and anticancer activity against oestrogen receptor positive human breast adenocarcinoma cancer cell line (MCF7) by Sulforhodamine B (SRB) assay. Molecular docking studies were carried out to study the binding mode of active compounds with receptor using Schrodinger v11.5. The antimicrobial activity results revealed that compounds d1, d2 and d3 have promising antimicrobial activity. Anticancer screening results indicated that compounds d6 and d7 were found to be the most active ones against breast cancer cell line. Furthermore, the molecular docking study demonstrated that compounds d1, d2, d3, d6 and d7 displayed good docking score within binding pocket of the selected PDB ID (1JIJ, 4WMZ and 3ERT) and has the potential to be used as lead compounds for rational drug designing.

【 授权许可】

Unknown