Synthesis and biological profile of substituted benzimidazoles

Chemistry Central Journal

Vasudevan Mani¹  Balasubramanian Narasimhan²  Sanjiv Kumar²  Kalavathy Ramasamy³  Siong Meng Lim³  Syed Adnan Ali Shah³  Neelam Vashist⁴  Surinder Singh Sambi⁵ 

[1] Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University;Faculty of Pharmaceutical Sciences, Maharshi Dayanand University;Faculty of Pharmacy, Universiti Teknologi MARA (UiTM);SGT College of Pharmacy, Shree Guru Gobind Singh Tricentenary (SGT) University;University School of Chemical Technology, Guru Gobind Singh Indraprastha University;

关键词: Benzimidazoles;    Synthesis;    Antimicrobial activity;    Anticancer activity;   

DOI  :  10.1186/s13065-018-0498-y

来源: DOAJ

【 摘 要 】

Abstract Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their IC50 values were more potent than 5-fluorouracil.

【 授权许可】

Unknown