The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides

International Journal of Molecular Sciences

Barbara Pisano¹  JoannaIzabela Lachowicz¹  Monica Piras¹  Sara Fais²  Geramano Orrù²  Cinzia Casu²  Alessandra Scano²  Kacper Szczepski³  Mariusz Jaremko³ 

[1] Department of Medical Sciences and Public Health, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Italy;Department of Surgical Science, OBL Oral Biotechnology Laboratory, University of Cagliari, 09124 Cagliari, Italy;Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia;

关键词: antimicrobial peptides;    antibiotics;    peptidomimetics;    polymers;    metal coplexes;   

DOI  :  10.3390/ijms21197349

来源: DOAJ

【 摘 要 】

Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: “The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant”. After 70 years, we are witnessing the fulfilment of Fleming’s prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections.

【 授权许可】

Unknown