Efficacy of a Combination Therapy for Difficulties Waking Up in Non-School-Attending Students

Journal of Clinical Medicine

Aki Arita¹  Hajime Kumagai¹  Ayako Urabe¹  Yoko Murase¹  Tetsuro Hoshino¹  Hiroyuki Sawatari¹  Maiko Yamaguchi¹  Masayo Baku¹  Ryujiro Sasanabe¹  Toshiaki Shiomi¹  Yuka Kiyohara¹  Noriyuki Konishi¹ 

[1] Department of Sleep Medicine and Sleep Disorders Center, Aichi Medical University Hospital, Nagakute 4801195, Japan;

关键词: aripiprazole;    blue-light exposure;    circadian rhythm sleep–wake disorder;    long sleep;    sleep hygiene guidance;    wake-up difficulty;   

DOI  :  10.3390/jcm11123271

来源: DOAJ

【 摘 要 】

School non-attendance due to difficulties waking up is increasing in Japan, and affected students are commonly diagnosed with orthostatic dysregulation (OD); however, OD-associated sleep problems are overlooked. To date, no sleep-medicine-based treatment for wake-up difficulties in non-school-attending students has been established. This study aimed to assess the efficacy of a novel combination therapy for these students. We assessed the combined effect of sleep hygiene guidance, low-dose aripiprazole administration (3 mg/day), and blue-light exposure on wake-up difficulty in 21 non-school-attending teenage patients. The patients were evaluated using sleep studies and questionnaires before and after treatment. The average subjective total sleep time calculated from sleep diaries before treatment in the patients was 10.3 h. The therapy improved wake-up difficulty by 85.7% and further improved school non-attendance by 66.7%. The subjective sleep time significantly decreased by 9.5 h after treatment (p = 0.0004). The self-rating Depression Scale and mental component summary of the 36-item Short-Form Health Survey significantly improved after treatment (p = 0.002 and p = 0.01, respectively). Wake-up difficulties were caused by the addition of a delayed sleep phase to the patients’ long sleep times. The novel combination therapy was effective in improving wake-up difficulty and mental quality of life in non-school-attending teenage students.

【 授权许可】

Unknown