Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana

Molecules

Shanmugam Maheshwaran¹  Janarthanam Rethavathi¹  Prince Edwin Das¹  Srinivasan Narasimhan¹  Imad A. Abu-Yousef²  Amin F. Majdalawieh²  Palmiro Poltronieri³ 

[1] Asthagiri Herbal Research Foundation, 162A, Perungudi Industrial Estate, Perungudi, Chennai 600096, India;Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666 Sharjah, United Arab Emirates;Institute of Sciences of Food Productions, CNR-ISPA, Lecce 73100, Italy;

关键词: α-mangostin;    anti-bacterial;    anti-fungal;    packaging;    textiles;    biomedical device;    semi-synthetic modification;   

DOI  :  10.3390/molecules22020275

来源: DOAJ

【 摘 要 】

The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the anti-microbial potential of the synthetic analogs showed higher bactericidal activity than the parent molecule. The anti-microbial studies proved that I E showed high anti-bacterial activity whereas I I showed the highest anti-fungal activity. Due to their microbicidal potential, modified α-mangostin derivatives could be utilized as active anti-microbial agents in materials for the biomedical and food industry.

【 授权许可】

Unknown