期刊论文详细信息
Frontiers in Microbiology
Gut Dysbiosis and Clostridioides difficile Infection in Neonates and Adults
Alexandra Bolocan2  Lia-Mara Diţu3  Veronica Lazăr3  Iulia-Magdalena Vasilescu5  Roxana Filip6  Gratiela Gradisteanu Pircalabioru7  Mariana-Carmen Chifiriuc8  Coralia Bleotu9 
[1] Academy of Romanian Scientists, Bucharest, Romania;Department of General Surgery, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania;Department of Microbiology, Faculty of Biology, University of Bucharest, Bucharest, Romania;Faculty of Medicine and Biological Sciences, Stefan cel Mare University of Suceava, Suceava, Romania;INBI “Prof. Dr. Matei Balş” – National Institute for Infectious Diseases, Bucharest, Romania;Regional County Emergency Hospital, Suceava, Romania;Research Institute of the University of Bucharest, Bucharest, Romania;The Romanian Academy, Bucharest, Romania;Ştefan S. Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania;
关键词: Clostridium difficile infection;    gut microbiota;    dysbiosis;    biotics;    fecal microbiota transplantation;   
DOI  :  10.3389/fmicb.2021.651081
来源: DOAJ
【 摘 要 】

In this review, we focus on gut microbiota profiles in infants and adults colonized (CDC) or infected (CDI) with Clostridioides difficile. After a short update on CDI epidemiology and pathology, we present the gut dysbiosis profiles associated with CDI in adults and infants, as well as the role of dysbiosis in C. difficile spores germination and multiplication. Both molecular and culturomic studies agree on a significant decrease of gut microbiota diversity and resilience in CDI, depletion of Firmicutes, Bacteroidetes, and Actinobacteria phyla and a high abundance of Proteobacteria, associated with low butyrogenic and high lactic acid-bacteria levels. In symptomatic cases, microbiota deviations are associated with high levels of inflammatory markers, such as calprotectin. In infants, colonization with Bifidobacteria that trigger a local anti-inflammatory response and abundance of Ruminococcus, together with lack of receptors for clostridial toxins and immunological factors (e.g., C. difficile toxins neutralizing antibodies) might explain the lack of clinical symptoms. Gut dysbiosis amelioration through administration of “biotics” or non-toxigenic C. difficile preparations and fecal microbiota transplantation proved to be very useful for the management of CDI.

【 授权许可】

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