Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

Biological Research

Moacyr JBM Rêgo¹  João LQ Silva-Filho¹  Eduardo AVF Ramalho¹  Carmelita BL Cavalcanti¹  Eduardo IC Beltrão¹  Marina FS Cartaxo¹  Maria BM Oliveira¹ 

[1] Federal University of Pernambuco;

关键词: Breast cancer;    Epigenetics;    Metastasis;    Methylation;    Polymorphism;   

DOI  :  10.1186/0717-6287-47-3

来源: DOAJ

【 摘 要 】

BACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190). Regarding to polymorphism of codon 249 the frequency of Arg249 allele presented 82% which was considered not statistically significant. CONCLUSIONS: There was not statistical significance to BRCA2 promoter methylation with any parameters chosen. However, our findings suggest that patients who present heterozygous genotype at codon 72 of p53 gene may have a major susceptibility to any type of metastasis and this could serve as potential auxiliary biomarker for poor prognosis.

【 授权许可】

Unknown