Modulators of MicroRNA Function in the Immune System

International Journal of Molecular Sciences

Yunhui Jia¹  Yuanyuan Wei² 

[1] Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;Department of Immunology, Shanghai Key laboratory of Bioactive Small Molecules, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China;

关键词: microRNA biogenesis;    immune cells;    miRNA site;    exosome;    macrophage;   

DOI  :  10.3390/ijms21072357

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) play a key role in fine-tuning host immune homeostasis and responses through the negative regulation of mRNA stability and translation. The pathways regulated by miRNAs are well characterized, but the precise mechanisms that control the miRNA-mediated regulation of gene expression during immune cell-development and immune responses to invading pathogens are incompletely understood. Context-specific interactions of miRNAs with other RNA species or proteins may modulate the function of a given miRNA. Dysregulation of miRNA function is associated with various human diseases, such as cardiovascular diseases and cancers. Here, we review the potential modulators of miRNA function in the immune system, including the transcription regulators of miRNA genes, miRNA-processing enzymes, factors affecting miRNA targeting, and intercellular communication.

【 授权许可】

Unknown