NF90 in Posttranscriptional Gene Regulation and MicroRNA Biogenesis

International Journal of Molecular Sciences

Kiyoshi Masuda²  Yuki Kuwano¹  Kensei Nishida¹  Kazuhito Rokutan¹ 

[1] Department of Stress Science, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan; E-Mails:;Department of Human Genetics and Public Health, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan; E-Mail:

关键词: NF90;    double-stranded RNA binding proteins;    posttranscriptional regulation;    microRNA biogenesis;   

DOI  :  10.3390/ijms140817111

来源: mdpi

【 摘 要 】

Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland