The role of microRNAs (miRNA) in circadian rhythmicity

Journal of genetics

Mirko Pegoraro¹  Eran Tauber1¹ 

[1] Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK$$

关键词: circadian clock;    chronobiology;    microRNA (miRNA);    posttranscriptional regulation;   

DOI  :  

学科分类：生物科学（综合）

来源: Indian Academy of Sciences

【 摘 要 】

MicroRNA (miRNA) is a recently discovered new class of small RNA molecules that have a significant role in regulating gene and protein expression. These small RNAs (∼22 nt) bind to 3′ untranslated regions (3′UTRs) and induce degradation or repression of translation of their mRNA targets. Hundreds of miRNAs have been identified in various organisms and have been shown to play a significant role in development and normal cell functioning. Recently, a few studies have suggested that miRNAs may be an important regulators of circadian rhythmicity, providing a new dimension (posttranscriptional) of our understanding of biological clocks. Here, we describe the mechanisms of miRNA regulation, and recent studies attempting to identify clock miRNAs and their function in the circadian system.

【 授权许可】

Unknown