Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

Frontiers in Pharmacology

Dong Yang¹  Lin-Hong Fan¹  Ping Wang¹  Yue Gao¹  Shi-Yu Chen¹  Xian-Li Meng²  Jia-Yi Sun²  Li Xiang² 

[1] College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;

关键词: Alzheimer’s disease;    traditional Chinese medicine;    β-amyloid;    apoptosis;    autophagy;    neuroinflammation;   

DOI  :  10.3389/fphar.2020.00497

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease characterized by memory loss and cognitive impairment. The major characteristics of AD are amyloid β plaques, apoptosis, autophagy dysfunction, neuroinflammation, oxidative stress, and mitochondrial dysfunction. These are mostly used as the significant indicators for selecting the effects of potential drugs. It is imperative to explain AD pathogenesis and realize productive treatments. Although the currently used chemical drugs for clinical applications of AD are effective in managing the symptoms, they are inadequate to achieve anticipated preventive or therapeutic outcomes. There are new strategies for treating AD. Traditional Chinese Medicine (TCM) has accumulated thousands of years of experience in treating dementia. Nowadays, numerous modern pharmacological studies have verified the efficacy of many bioactive ingredients isolated from TCM for AD treatment. In this review, representative TCM for the treatment of AD are discussed, and among these herbal medicines, the Lamiaceae family accounts for the highest proportion. It is concluded that monomers and extracts from TCM have potential therapeutic effect for AD treatment.

【 授权许可】

Unknown