Hepatic Macrophages in Liver Injury

Frontiers in Immunology

Zhao Shan¹  Cynthia Ju² 

[1] Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, China;Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States;

关键词: Kupffer cells;    monocyte-derived macrophages;    liver injury;    microenvironmental cues;    cellular crosstalk;   

DOI  :  10.3389/fimmu.2020.00322

来源: DOAJ

【 摘 要 】

Ample evidence suggests that hepatic macrophages play key roles in the injury and repair mechanisms during liver disease progression. There are two major populations of hepatic macrophages: the liver resident Kupffer cells and the monocyte-derived macrophages, which rapidly infiltrate the liver during injury. Under different disease conditions, the tissue microenvironmental cues of the liver critically influence the phenotypes and functions of hepatic macrophages. Furthermore, hepatic macrophages interact with multiple cells types in the liver, such as hepatocytes, neutrophils, endothelial cells, and platelets. These crosstalk interactions are of paramount importance in regulating the extents of liver injury, repair, and ultimately liver disease progression. In this review, we summarize the novel findings highlighting the impact of injury-induced microenvironmental signals that determine the phenotype and function of hepatic macrophages. Moreover, we discuss the role of hepatic macrophages in homeostasis and pathological conditions through crosstalk interactions with other cells of the liver.

【 授权许可】

Unknown