Liver Injury and the Macrophage Issue: Molecular and Mechanistic Facts and Their Clinical Relevance

International Journal of Molecular Sciences

Siyer Roohani¹  Frank Tacke¹ 

[1] Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité University Medicine Berlin, 13353 Berlin, Germany;

关键词: hepatic macrophages;    Kupffer cells;    monocyte-derived macrophages;    acute liver injury;    chronic liver injury;    NAFLD;   

DOI  :  10.3390/ijms22147249

来源: DOAJ

【 摘 要 】

The liver is an essential immunological organ due to its gatekeeper position to bypassing antigens from the intestinal blood flow and microbial products from the intestinal commensals. The tissue-resident liver macrophages, termed Kupffer cells, represent key phagocytes that closely interact with local parenchymal, interstitial and other immunological cells in the liver to maintain homeostasis and tolerance against harmless antigens. Upon liver injury, the pool of hepatic macrophages expands dramatically by infiltrating bone marrow-/monocyte-derived macrophages. The interplay of the injured microenvironment and altered macrophage pool skews the subsequent course of liver injuries. It may range from complete recovery to chronic inflammation, fibrosis, cirrhosis and eventually hepatocellular cancer. This review summarizes current knowledge on the classification and role of hepatic macrophages in the healthy and injured liver.

【 授权许可】

Unknown