Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

Molecules

关键词: Aminophosphonates;    microwave irradiation;    synthesis;    antiviral activity;   

DOI  :  10.3390/11090666

来源: DOAJ

【 摘 要 】

A simple, efficient, and general method has been developed for the synthesis ofvarious α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes andaniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwaveirradiation without solvents and catalysts. The products were characterized by elementalanalysis, IR, 1H-NMR, 13C- and 31P-NMR spectra. The X-ray crystallographic data of therepresentative compound 4l was determined. The new α-aminophosphonate derivatives werefound to possess moderate to good antiviral activity.

【 授权许可】

Unknown