Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

Molecules

Yingshu Xu¹  Kai Yan¹  Baoan Song¹  Gangfang Xu¹  Song Yang¹  Wei Xue¹  Deyu Hu¹  Ping Lu¹  Guiping Ouyang¹  Linhong Jin¹ 

[1] Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China; E-mails:

关键词: Aminophosphonates;    microwave irradiation;    synthesis;    antiviral activity;   

DOI  :  10.3390/11090666

来源: mdpi

【 摘 要 】

A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, ¹H-NMR, ¹³C- and ³¹P-NMR spectra. The X-ray crystallographic data of the representative compound 4l was determined. The new α-aminophosphonate derivatives were found to possess moderate to good antiviral activity.

【 授权许可】

Unknown   
© 2006 by MDPI (http://www.mdpi.org).