m6A Regulatory Gene-Mediated Methylation Modification in Glioma Survival Prediction

Frontiers in Genetics

Zhonghua Shi¹  Ping Zheng²  Fei Shi³  Guiyun Zhang³  Yisong Lv⁴ 

[1] Department of Neurosurgery, 904th Hospital of PLA, Wuxi, China;Department of Neurosurgery, Shanghai Pudong New Area People’s Hospital, Shanghai, China;Department of Neurovascular Intervention and Neurosurgery, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China;School of Continuing Education, Shanghai Jiao Tong University, Shanghai, China;

关键词: glioblastoma;    low grade glioma;    TCGA;    M6A;    immune infiltration;   

DOI  :  10.3389/fgene.2022.873764

来源: DOAJ

【 摘 要 】

The median survival of patients with gliomas is relatively short. To investigate the epigenetic mechanisms associated with poor survival, we analyzed publicly available datasets from patients with glioma. This analysis revealed 12 prognosis-related m6A regulatory genes that may be responsible for poor prognosis. These genes may be involved in genomic changes inherent to oxidative phosphorylation, adipogenesis, hedgehog signaling, and Myc signaling. We reconstructed a risk model with univariate and multivariate Cox analyses and identified older age and the m6A risk score as independent risk factors for predicting the prognosis of glioma patients, which is associated with glioma immune infiltration. In conclusion, m6A regulatory genes may serve as both reliable biomarkers and potential targets to increase the chance of survival of patients with glioma.

【 授权许可】

Unknown