Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties

Journal of Enzyme Inhibition and Medicinal Chemistry

Daria Szymanowska¹  Ewa Tykarska²  Joanna Kobus-Cisowska³  Maciej Kozak⁴  Kornelia Lewandowska⁵  Judyta Cielecka-Piontek⁶  Anna Stasiłowicz⁶  Tomasz Plech⁷  Andrzej Miklaszewski⁸  Jacek Jenczyk⁹ 

[1] Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences;Department of Chemical Technology of Drugs, Poznan University of Medical Sciences;Department of Gastronomy Sciences and Functional Foods, Faculty of Food Science and Nutrition, Poznan University of Life Sciences;Department of Macromolecular Physics, Adam Mickiewicz University in Poznan;Department of Molecular Crystals Institute, Molecular Physics Polish Academy Sciences;Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences;Department of Pharmacology, Medical University of Lublin;Division of Functional Nanomaterials, Poznan University of Technology;NanoBioMedical Centre, Adam Mickiewicz University;

关键词: curcumin;    piperine;    cyclodextrin;    hyaluronidase;    acetylcholinesterase;   

DOI  :  10.1080/14756366.2020.1801670

来源: DOAJ

【 摘 要 】

The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.

【 授权许可】

Unknown