Journal of Enzyme Inhibition and Medicinal Chemistry | |
Hydroxypropyl-β-cyclodextrin as an effective carrier of curcumin – piperine nutraceutical system with improved enzyme inhibition properties | |
Daria Szymanowska1  Ewa Tykarska2  Joanna Kobus-Cisowska3  Maciej Kozak4  Kornelia Lewandowska5  Judyta Cielecka-Piontek6  Anna Stasiłowicz6  Tomasz Plech7  Andrzej Miklaszewski8  Jacek Jenczyk9  | |
[1] Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences;Department of Chemical Technology of Drugs, Poznan University of Medical Sciences;Department of Gastronomy Sciences and Functional Foods, Faculty of Food Science and Nutrition, Poznan University of Life Sciences;Department of Macromolecular Physics, Adam Mickiewicz University in Poznan;Department of Molecular Crystals Institute, Molecular Physics Polish Academy Sciences;Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences;Department of Pharmacology, Medical University of Lublin;Division of Functional Nanomaterials, Poznan University of Technology;NanoBioMedical Centre, Adam Mickiewicz University; | |
关键词: curcumin; piperine; cyclodextrin; hyaluronidase; acetylcholinesterase; | |
DOI : 10.1080/14756366.2020.1801670 | |
来源: DOAJ |
【 摘 要 】
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between the components of the system were defined by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application of hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility of the curcumin–piperine system, its permeability through biological membranes (gastrointestinal tract, blood–brain barrier) as well as the antioxidant, antimicrobial and enzyme inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
【 授权许可】
Unknown