International Journal of Molecular Sciences | 卷:22 |
Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic®/Hyaluronate Hydrogel | |
Paola Mura1  Francesca Maestrelli1  Elena Talero2  Sara García-Gil2  Ana-María Fernández-Romero3  María Luisa González-Rodríguez3  Antonio M. Rabasco3  | |
[1] Department of Chemistry “Ugo Schiff” (DICUS), University of Florence, Via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy; | |
[2] Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, C/Prof. García González 2, 41012 Seville, Spain; | |
[3] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, C/Prof. García González 2, 41012 Seville, Spain; | |
关键词: curcumin; cyclodextrin; epichlorohydrin-β-cyclodextrin; pluronic; hydrogel; inflammatory disease; | |
DOI : 10.3390/ijms222413566 | |
来源: DOAJ |
【 摘 要 】
Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hydrogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic® F-127/hyaluronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hydrogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases.
【 授权许可】
Unknown