Preparation, Characterization and Evaluation of the Anti-Inflammatory Activity of Epichlorohydrin-β-Cyclodextrin/Curcumin Binary Systems Embedded in a Pluronic®/Hyaluronate Hydrogel

International Journal of Molecular Sciences

卷:22

Paola Mura¹  Francesca Maestrelli¹  Elena Talero²  Sara García-Gil²  Ana-María Fernández-Romero³  María Luisa González-Rodríguez³  Antonio M. Rabasco³ 

[1] Department of Chemistry “Ugo Schiff” (DICUS), University of Florence, Via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy;

[2] Department of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, C/Prof. García González 2, 41012 Seville, Spain;

[3] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, C/Prof. García González 2, 41012 Seville, Spain;

关键词: curcumin;    cyclodextrin;    epichlorohydrin-β-cyclodextrin;    pluronic;    hydrogel;    inflammatory disease;   

DOI  :  10.3390/ijms222413566

来源: DOAJ

【 摘 要 】

Curcumin (Cur) is an anti-inflammatory polyphenol that can be complexed with polymeric cyclodextrin (CD) to improve solubility and bioavailability. The aim of the present work was to prepare a CurCD hydrogel to treat inflammatory skin conditions. Epichlorohydrin-β-CD (EpiβCD) was used as polymeric CD. To characterize the binary system, solid-state and in-solution studies were performed. Afterwards, an experimental design was performed to optimize the hydrogel system. Finally, the CurEpiβCD hydrogel system was tested for anti-inflammatory activity using a HaCat psoriasis cell model. Co-grinded Cur/EpiβCD binary system showed a strong interaction and Curcumin solubility was much improved. Its combination with Pluronic^® F-127/hyaluronate hydrogel demonstrated an improvement in release rate and Curcumin permeation. After testing its anti-inflammatory activity, the system showed a significant reduction in IL-6 levels. Hydrogel-containing CurEpiβCD complex is a great alternative to treat topical inflammatory diseases.

【 授权许可】

Unknown