Anti-Inflammatory Effects of Novel Glycyrrhiza Variety Wongam In Vivo and In Vitro

Applied Sciences

Wonnam Kim¹  Jong-Sik Jin²  Yun-Mi Kang³  Hyo-Jin An³  Jong-Hyun Lee⁴  Jeonghoon Lee⁵ 

[1] Cnh Center for Cancer Research, 462 Bongeunsa-ro, Gangnam-gu, Seoul 06154, Korea;Department of Oriental Medicine Resources, Jeonbuk National University, 79 Gobong-ro, Iksan 54596, Jeollabuk-do, Korea;Department of Pharmacology, College of Korean Medicine, Sangji University, 83 Sangjidae-gil, Wonju 26339, Gangwon-do, Korea;Department of Pharmacy, College of Pharmacy, Dongduk Women’s University, 60 Hwarang-ro 13-gil, Seongbuk-gu, Seoul 02748, Korea;Herbal Crop Research Division, National Institue of Horticultural and Herbal Science, Rural Development Administration, 92 Bisan-ro, Eumseong 27709, Chungbuk, Korea;

关键词: allergy;    inflammation;    novel Glycyrrhiza varieties;    Wongam;    mast cell activation;    anaphylaxis;   

DOI  :  10.3390/app112210822

来源: DOAJ

【 摘 要 】

Licorice is the common name of Glycyrrhiza species, which is an important plant for edible and medicinal purposes; however, Glycyrrhiza resources have become limited because of desertification, depletion of natural resources, and environmental restrictions. For this reason, a novel Glycyrrhiza variety named Wongam, a hybrid of G. glabra and G. uralensis, was developed by the Korea Rural Development Administration. To elucidate the antiallergic inflammatory effects of Wongam, we investigated its effects using a compound-48/80-induced anaphylaxis in vivo model and PMA/A23187-stimulated HMC-1 cells and immunoglobulin E (IgE)/DNP-stimulated RBL-2H3 cells in in vitro models. Wongam treatment reduced mortality and serum IgE levels and downregulated proinflammatory cytokines and chemokines in a compound-48/80-induced anaphylaxis mouse model. Wongam decreased histamine release and the expression of proinflammatory cytokines in HMC-1 and RBL-2H3 cells. Wongam treatment downregulated the expression of chemokines, T helper 2 cytokines, and cell surface antigens in PMA/A23187-stimulated HMC-1 cells. We confirmed that these effects were associated with the inhibition of the MAPK and NF-κB signaling pathways by Wongam. The present study suggests that Wongam ameliorates mast-cell-mediated allergic inflammatory responses by reducing mast cell activation and may serve as an effective agent for the prevention and treatment of allergic inflammatory responses.

【 授权许可】

Unknown