期刊论文详细信息
Molecules
Treatment with, Resveratrol, a SIRT1 Activator, Prevents Zearalenone-Induced Lactic Acid Metabolism Disorder in Rat Sertoli Cells
Hao Zheng1  Zongping Liu1  Xuezhong Liu1  Hui Zou1  Yan Yuan1  Nannan Feng1  Wanglong Zheng1  Peirong Cai1  Jianhong Gu1  Jianchun Bian1 
[1] College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China;
关键词: Sertoli cells;    zearalenone;    lactic acid;    SIRT1;    resveratrol;   
DOI  :  10.3390/molecules24132474
来源: DOAJ
【 摘 要 】

Zearalenone (ZEA) interferes with the function of the male reproductive system, but its molecular mechanism has yet to be completely elucidated. Sertoli cells (SCs) are important in the male reproductive system. Silencing information regulator 1 (SIRT1) is a cell metabolism sensor and resveratrol (RSV) is an activator of SIRT1. In this study we investigated whether SIRT1 is involved in the regulation of ZEA-induced lactate metabolism disorder in SCs. The results showed that the cytotoxicity of ZEA toward SCs increased with increasing ZEA concentration. Moreover, ZEA induced a decrease in the production of lactic acid and pyruvate of SCs and inhibited the expression of glycolytic genes and lactic acid production-related proteins. ZEA also led to a decreased expression of SIRT1 in energy receptors and decreased ATP levels in SCs. However, the ZEA-induced cytotoxicity and decline in lactic acid production in SCs were alleviated by the use of RSV, which is an activator of SIRT1. In summary, ZEA decreased lactic acid production in SCs, while the treatment with an SIRT1 activator, RSV, restored the inhibition of lactic acid production in SCs and reduced cytotoxicity of ZEA toward SCs.

【 授权许可】

Unknown   

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