Magnesium Enhanced Fibrinolytic Activity of Protease from Schizophyllum commune

Taiwania

Shiu-Nan Chen¹  Chung-Lun Lu² 

[1] Department of Life Science, College of Life Science, National Taiwan University, 1, Sec. 4, Roosevelt Road, National Taiwan University, Taipei 10617 Taiwan.;Institute of Fisheries Science, National Taiwan University, 1, Sec. 4, Roosevelt Road, National Taiwan University, Taipei 10617 Taiwan.;

关键词: Fibrinolytic protease;    Schizophyllum commune;    Magnesium;    Anti-thrombotic;    Thromboelastography;   

DOI  :  10.6165/tai.2010.55(2).117

来源: DOAJ

【 摘 要 】

Prevention and therapy of thrombotic diseases have attracted much attention in developed countries during recent years. Investigators have been looking for cheaper and safer thrombolytic agents for therapy of thrombotic diseases. Recently, we have discovered a fibrinolytic protease from Schizophyllum commune. In this study, the protease was proven to degrade blood clot effectively. Seven divalent metal ions were used to test the selectiveness on enhancing protease activity. The treated rat blood was traced by thromboelastography to assess the viscoelastic properties of whole blood. As the result, fibrinolytic activity of the protease was enhanced remarkably by Mg2+ in reducing the strength of blood clot and showed the innovative anti-thrombotic effects. This is the first study of anti-thrombotic effects from fungal-derived fibrinolytic protease using thromboelastography and delineates the efficacy of magnesium supplementation in enhancement of thrombolytic activity from S. commune fibrinolytic protease.

【 授权许可】

Unknown