High Incidence of Zika or Chikungunya Infection among Pregnant Women Hospitalized due to Obstetrical Complications in Northeastern Brazil—Implications for Laboratory Screening in Arbovirus Endemic Area

Viruses

PriscilaM. S. Castanha¹  ErnestoT. A.Marques¹  IracemaJ. A. A. Jacques²  Mariade FátimaP. M. Albuquerque²  Cynthia Braga²  AnaB. G. Guimarães²  PaulaA. S. Oliveira²  MaríliaA. Sena²  CelinaM. T. Martelli²  YasmimL. Silva²  RafaelF. O. França²  MarliT. Cordeiro²  MariaAlmericeL. Silva²  Leila Katz³  GabrielaD. M. Albuquerque³  RaisaO. Pereira³  CamilaA. M. C. de Albuquerque³ 

[1] Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA;Instituto Aggeu Magalhães, Fundação Oswaldo Cruz Pernambuco, Recife, PE, CEP 50740-465, Brazil;Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, CEP 50070-550, Brazil;

关键词: Zika virus;    dengue virus;    chikungunya virus;    pregnancy complications;   

DOI  :  10.3390/v13050744

来源: DOAJ

【 摘 要 】

The diagnostic of arbovirus-related obstetric complications in high-risk pregnancy and childbirth care is challenging, especially in endemic areas. We conducted a prospective study to track active or recent Zika (ZIKV), dengue (DENV), or chikungunya (CHIKV) virus infection among hospitalized pregnant women (PW) with obstetric complications in a hospital at the epicenter of Zika outbreak and ZIKV-related microcephaly in Brazil. Clinical data and blood samples were collected at enrollment and 10 days after the admission of study participants, between October 2018 and May 2019. Further clinical data were extracted from medical records. Samples were screened by molecular and serological tests. Out of 780 participants, 93.1% (95%CI: 91.1–94.7%) presented previous DENV exposure (IgG). ZIKV, CHIKV, and/or DENV laboratory markers of recent or active infection were detected in 130 PW, yielding a prevalence of 16.6% (95%CI: 14.2–19.5%); 9.4% (95%CI: 7.4–11.7%), 7.4% (95%CI: 5.7–9.7%), and 0.38% (95%CI: 0.1–1.2%) of CHIKV, ZIKV, and DENV infections, respectively. Most ZIKV infections were detected by molecular assays (89.6%), while CHIKV infections were detected by serology (95.9%). Our findings highlight the need for arbovirus infections screening in PW with obstetrical complications, potentially associated to these infections in endemic areas regardless of the signs or symptoms suggestive of arboviral disease.

【 授权许可】

Unknown