Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

Materials

Jonny James Blaker¹  William Stephen Ambler¹  Marco Andrey Frade²  Guilherme Caetano³  Paulo Bártolo³  Weiguang Wang³  Carl Diver³  Parthasarathi Mandal³ 

[1] Bio/Active Materials Group, School of Materials, The University of Manchester, Manchester M13 9PL, UK;Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, SP 14049-900, Brazil;Manchester Institute of Biotechnology, School of Mechanical, Aerospace and Civil Engineering, University of Manchester, Manchester M13 9PL, UK;

关键词: biofabrication;    composite materials;    graphene;    hydrophilicity;    polycaprolactone;    scaffolds;    surface modification;    tissue engineering;   

DOI  :  10.3390/ma9120992

来源: DOAJ

【 摘 要 】

Scaffolds are physical substrates for cell attachment, proliferation, and differentiation, ultimately leading to the regeneration of tissues. They must be designed according to specific biomechanical requirements, i.e., certain standards in terms of mechanical properties, surface characteristics, porosity, degradability, and biocompatibility. The optimal design of a scaffold for a specific tissue strongly depends on both materials and manufacturing processes, as well as surface treatment. Polymeric scaffolds reinforced with electro-active particles could play a key role in tissue engineering by modulating cell proliferation and differentiation. This paper investigates the use of an extrusion-based additive manufacturing system to produce poly(ε-caprolactone) (PCL)/pristine graphene scaffolds for bone tissue applications and the influence of chemical surface modification on their biological behaviour. Scaffolds with the same architecture but different concentrations of pristine graphene were evaluated from surface property and biological points of view. Results show that the addition of pristine graphene had a positive impact on cell viability and proliferation, and that surface modification leads to improved cell response.

【 授权许可】

Unknown