Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

Molecules

Deepak Gupta¹  Sheeba Varghese Gupta²  Vijaykumar Sutariya²  Deepak Bhatia³  Vivek Dave⁴ 

[1] Department of Pharmaceutical Sciences, School of Pharmacy, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA;Department of Pharmaceutical Sciences, USF College of Pharmacy, Tampa, FL 33612, USA;ICPH Fairfax Bernard J. Dunn School of Pharmacy, Shenandoah University, Fairfax, VA 22031, USA;Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY 14618, USA;

关键词: chemistry;    salt;    water solubility;    routes of administration;    physicochemical;    stability;    degradation;   

DOI  :  10.3390/molecules23071719

来源: DOAJ

【 摘 要 】

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes.

【 授权许可】

Unknown