Modeling of Viral Dynamics after Liver Transplantation in Patients with Chronic Hepatitis B and D

Biomath

Eva Herrmann¹  Natalie Filmann¹ 

[1] Goethe University Frankfurt;

关键词: Infectious diseases;    hepatitis B and D;    viral dynamics;    PK/PD;   

DOI  :  10.11145/j.biomath.2012.09.022

来源: DOAJ

【 摘 要 】

Viral kinetic models have become an important tool for understanding the main biological processes behind the dynamics of chronic viral diseases and optimizing effectiveness of anti-viral therapy. We analyzed the dynamics of hepatitis B and D co-infection (HBV/HDV) and the pharmacokinetics/pharmacodynamics of the reinfection prophylaxis with polyclonal antibodies after liver transplantation. Therefore we developed a mechanistic model consisting of a system of ordinary differential equations. This model was fitted by analyzing the kinetics of HBV/HDV viremia after liver transplantation in patient data and correlated with the reinfection prophylaxis dosing schemes. The results suggest that this modeling approach may help to optimize reinfection prophylaxis.

【 授权许可】

Unknown