Mechanistic Modelling of Radiation Responses

Cancers

KevinM. Prise¹  StephenJ. McMahon² 

[1] Cell Biology, Queen’s University Belfast, Belfast BT9 7AE, Northern Ireland, UK;;Centre for Cancer Research &

关键词: radiation;    radiobiology;    mathematical modelling;    mechanistic modelling;    track structure;    DNA repair;    cell death;   

DOI  :  10.3390/cancers11020205

来源: DOAJ

【 摘 要 】

Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.

【 授权许可】

Unknown