Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

International Journal of Molecular Sciences

Po-Yuan Ke¹ 

[1] Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan;

关键词: autophagy;    selective autophagy;    liver;    liver disease;    hepatitis;    steatosis;    fibrosis;    cirrhosis;    hepatocellular carcinoma;   

DOI  :  10.3390/ijms20020300

来源: DOAJ

【 摘 要 】

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials through vacuole-mediated sequestration and subsequent delivery to lysosomes for degradation, thus maintaining cellular homeostasis and the integrity of organelles. Autophagy has emerged as playing a critical role in the regulation of liver physiology and the balancing of liver metabolism. Conversely, numerous recent studies have indicated that autophagy may disease-dependently participate in the pathogenesis of liver diseases, such as liver hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. This review summarizes the current knowledge on the functions of autophagy in hepatic metabolism and the contribution of autophagy to the pathophysiology of liver-related diseases. Moreover, the impacts of autophagy modulation on the amelioration of the development and progression of liver diseases are also discussed.

【 授权许可】

Unknown