Natural Dibenzo-α-Pyrones and Their Bioactivities

Molecules

Linyun Fu¹  Haiyu Luo¹  Weibo Sun¹  Daowan Lai¹  Ligang Zhou¹  Ziling Mao¹ 

[1] MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China;

关键词: dibenzo-α-pyrones;    dibenzo-α-pyranones;    6H-benzo[c]chromen-6-ones;    6H-dibenzo[b,d]pyran-6-ones;    biological activities;   

DOI  :  10.3390/molecules19045088

来源: DOAJ

【 摘 要 】

Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.

【 授权许可】

Unknown