Natural Dibenzo-α-Pyrones and Their Bioactivities

Molecules

Ziling Mao¹  Weibo Sun¹  Linyun Fu¹  Haiyu Luo¹  Daowan Lai¹ 

[1] id="af1-molecules-19-05088">MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, Chi

关键词: dibenzo-α-pyrones;    dibenzo-α-pyranones;    6H-benzo[c]chromen-6-ones;    6H-dibenzo[b;    d]pyran-6-ones;    biological activities;   

DOI  :  10.3390/molecules19045088

来源: mdpi

【 摘 要 】

Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic, antioxidant, antiallergic, antimicrobial, antinematodal, and acetylcholinesterase inhibitory properties. Dibenzo-α-pyrones are biosynthesized via the polyketide pathway in microorganisms or metabolized from plant-derived ellagitannins and ellagic acid by intestinal bacteria. At least 53 dibenzo-α-pyrones have been reported in the past few decades. This mini-review aims to briefly summarize the occurrence, biosynthesis, biotransformation, as well as their biological activities and functions. Some considerations related to synthesis, production and applications of dibenzo-α-pyrones are also discussed.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.