Identification of Potential SARS-CoV-2 CD8+ T Cell Escape Mutants

Vaccines

Syed Faraz Ahmed¹  Matthew R. McKay¹  Muhammad Saqib Sohail²  Ahmed Abdul Quadeer² 

[1] Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, VIC 3010, Australia;Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China;

关键词: SARS-CoV-2;    COVID-19;    CD8⁺ T cell epitopes;    immunoprevalent;    immune escape;    mutations;   

DOI  :  10.3390/vaccines10040542

来源: DOAJ

【 摘 要 】

Memory SARS-CoV-2-specific CD8⁺ T cell responses induced upon infection or COVID-19 vaccination have been important for protecting against severe COVID-19 disease while being largely robust against variants of concern (VOCs) observed so far. However, T cell immunity may be weakened by genetic mutations in future SARS-CoV-2 variants that lead to widespread T cell escape. The capacity for SARS-CoV-2 mutations to escape memory T cell responses requires comprehensive experimental investigation, though this is prohibited by the large number of SARS-CoV-2 mutations that have been observed. To guide targeted experimental studies, here we provide a screened list of potential SARS-CoV-2 T cell escape mutants. These mutants are identified as candidates for T cell escape as they lie within CD8⁺ T cell epitopes that are commonly targeted in individuals and are predicted to abrogate HLA–peptide binding.

【 授权许可】

Unknown